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J Integrative Medicine 2004;8:97-101
Autologous Vaccine
 

Autologous Vaccine from isopropyl-Alcohol Denatured Breast Cancer Tissue Prevented Cancer Recurrence without Chemotherapy or Radiotherapy

Tsuneo Kobayashi MD
 

ABSTRACT and Keywords

Cancer cell growth is fostered by lowered immunity and defective immunosurveillance.

To correct the lowered immunity and defective immunosurveillance, patients were treated with “Sun Advance” (an herbal medicinal formulation), s-ITC(systemic immunothermochemotherapy) and an isopropyl alcohol-prepared autologous vaccine of resected breast cancer tissue. It was found that tumor mass and small metastases of the breast cancer could be reversed and recurrence of the breast cancer could be prevented with these treatments. The breast maintained a favorable cosmetic result because no radical surgery was performed. This article describes two case reports of breast tumors reversed with the above treatments plus systemic hyperthermia.

Key words

Autologous vaccine
Soaked in alcohol
No radical surgery
Hyperthermia　

INTRODUCTION

It is widely accepted that surgical excision should be performed to remove a cancer mass. However, many recurrence occur because the cause –lowered immunity and defective immunosurveillance-was not resolved. In the following two cases, “Sun Advance” herbal medicinal formula(4-6) was prescribed and systemic immunothermochemotherapy(s-ITC)(1-2) was performed to solve the lowered immunity and defective immunosurveillance.  This was followed by autologous vaccine made from the resected cancer lump. This autologous vaccine was prepared by soaking the entire resected cancer mass in 100% isopropyl alcohol for 10 minutes and washing sterilized physiological saline 2　times. The alcohol was used to denature the cancer cell proteins. This denatured cancerous tumor was then returned to its original position and the incision was closed with sutures. Immune activity gradually increased to normal after the treatments. One patients was nine years without a recurrence at which time June, 2003.  The other patient with an advanced invasive breast cancer had no recurrence after three year at which time June ,2003.

CASE REPORT 1

March 4,1994, T.S., a 58 year old female was diagnosed with tubular adenocarcinoma of the breast stage III. She was not treated until October 1994 at which time her treatment included radical mastectomy, radiotherapy(30 Grey) and chemotherapy( 10 treatments of  combination of cyclophosphamide  100mg, methotrexate  40mg and 5-FU 600mg.)

One year later , a tumor metastasis appeared on her left upper extremity of 5 cm diameter and approximately 10 small lymph node metastases appeared near the surgical excision site. She was treated with “Sun Advance” herbal medicinal formula(4-6). Also, seven s-ITC(1-2) treatments( one per week) and five local hyperthermia(3) treatments were performed using radiofrequency on the metastatic mass located on her left upper extremity. On Sept 20, 1994 ,she had the following abnormal tumor markers: STN(35.8U/L), BCA225(173 U/ml), CA15-3(23U/ml) and TPA(164U/L).

On September 21,1994, her upper extremity metastasis had excised under lumbar anesthesia. All most of the entire excised neoplastic tumor mass was soaked in 100% isopropyl alcohol for 10 minutes, washed in sterile saline 2 times and then returned to its original position, thus creating an autologous vaccine of the cancer tissue. The incision was closed with sutures.

Over the two months following autologous vaccine treatment, the alcohol-denatured tumor mass gradually diminished in size and simultaneously the approximately 10 small lymph node metastases also disappeared. The tumor markers drawn at this time revealed within normal range ,June 9, 2003. Nine years after the autologous vaccine treatment, there was no evidence of recurrence.

CASE REPORT 2

May 11, 2001, H.N., a 50 year old female presented with a 2 cm mass which was ultimately diagnosed as invasive ductal carcinoma. She refused radical mastectomy. Two months later, July9, 2001, having received no treatment, the tumor had increased to 5 cm in diameter. At this point, she was treated with “ Sun Advance” herbal medicinal formula(4-6) and four s-ITC treatments(1-2), one per week. The breast tumor decreased to 2 cm diameter.

On July 1,2001, she was noted to have the following elevated tumor marker value: CA15-3(23),polyamine(63.4), deoxypridinoline(9.2), natural　killer cell activity was low at 15.2%.

On July 5, 2001, she underwent a lumpectomy. Pathology revealed invasive ductal carcinoma. An autologous vaccine was made from the breast cancer tumor tissue by the following procedure: The breast tumor was excised. The entire excised neoplastic tumor mass was soaked in 100% isopropyl alcohol for 10 minutes, washed in sterile saline 2 times and then returned to its original position. The incision was closed with sutures.

There was no recurrence at 3 year follow-up . She had not received any chemotherapy or radiotherapy. At one year follow-up, the tumor markers were decreased: CA15-3 decreased from23 to 12 U/L, deoxypridinoline decreased from 9.2 to 6.2. Polyamine decreased from 63.4 to 23. These are now within normal range. Natural killer activity was increased to 59.4~60.4%. T cell number was also increased to 1665.

DISCUSSION

This the first report of cancer remission obtained by treating the underlying cause-lowered immunity and defective immunosurveillance-plus use of autologous vaccine from isopropyl alcohol-denatured breast cancer tissue. No chemotherapy or radiotherapy were used.

In both of the patients, natural killer cell activity gradually increased after autologous vaccine made from breast cancer tissue. T-cell number did not increase in case 1 because of chronic hepatitis C virus infection. In case 2, T-cell number did increase from 788 to 1665. Lowered immunity and defective immunosurveillance may have been changed by the s-ITC. Hyperthermic treatment may also play the induction of tumor-specific immunogenecities of HSP. The autologous breast cancer vaccine successfully prevented cancer recurrence for nine years in advanced invasive breast cancer.

After the autologous breast cancer vaccine, it is felt that the WBC’s lymphocytes and macrophages ingest the denatured cancer tissue, thus decrease the size of the repositioned tumor mass. As a result, the patients recovered appropriate immune activity, immunosurveillance capabilities were restored. This resulted in removal of the denatured breast cancer mass by the immune system as well as the recognition of tumor metastases as non-self. It is thought that micrometastases regressed after recovery of immunity.

REFERENCES

1. Shigeru Hayashida et al. Effect of BRM –induced systemic Hyperthermia combined with Immunochemothermotherapy on advanced breast cancer with metastases 5^th International Symph. On Hyperthermic Oncology;1987:361

2. Yoshio Takeda et al. Effect of BRM –induced systemic Hyperthermia combined with Immunochemothermotherapy on metastatic testicular cancer. 5^th International Symph. On Hyperthermic Oncology; 1987:369

3.  Shigeru Hayashida et al. The clinical effect of hyperthermia combined induced hypertensive chemotherapy  Jpn. J. Cancer chemotherapy, 1984, 11(6): 1218-1224

4.  Kimito Sugimoto et al.  The effect of the Antitumor Herb medicine” Sun Advance” in mice. Proc. Symp. WAKAN-YAKU 1982; 15: 224-227

5.  Tomoko Tanimuzu et al. New Approach to the Chinese Herb medicine: Inhibition by Herb medicine” Sun Advance” of SV40 virus transformation in mouse cells. Proc. Symp. WAKAN-YAKU, 1982; 15: 228-233

6.  Tokio Jo et al. The effect of comprehensive Herb medicine “ Sun Advance” to reproductive organ. J. of WAKAN-YAKU 1985; 2: 592-595

7.  Udono H.,Stirivasta PK Comparision of tumor specific immunogenecities of stress-induced proteins gp96,hsp90 and hsp70. J.Immunol. 152:5398-5403,1994.

8.  Binder R.J. et al. CD91: a receptor for heat shock protein gp96  Nature Immunol. 1:151-155,2000.

Index of Article Authors
Majid Ali, MD
Omar Ali, MD
Mary Ann Carroll, RN
Alfred Fayemi, MD
C.Grieder-Brandenburger, RN
Judy Juco, MD
Tsuneo Kobayashi MD
Jean A. Monro, MB, BS
(This index is incomplete and will be completed shortly)

Past and
Current Editors
Omar Ali, M.D.
Robert Atkins, M.D.
Robert Bradford, D.Sc
Paul Cheney, M.D., Ph.D.
Steven Davies, M.D.
Alfred O. Fayemi, M.D.
Claus Hanke, M.D.
Doug Hutto, N.D.
Judy Juco, M.D.
Paris Kidd, Ph.D.
Oscar Kruesi, M.D.
Derrick Lonsdale, M.D.
D. Vijen Poleszynski, B.S.
Christine Radulescu, Ph.D.
Ray Russamono, M.D.
Susan Test, Ph.D.
Lowell Weiner, D.D.S.
John C. Williams, M.D.

The Journal of Integrative Medicine shall not be held responsible for statements of the contributing authors. The views and opinions expressed are those of the submitting authors and do not necessarily reflect those of The Journal of Integrative Medicine, The American Academy of Integrative Medicine,
The American Academy of Preventive Medicine, any advertisers or staff members of The Journal of Integrative Medicine
 

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The Journal of Integrative Medicine shall not be held responsible for statements of the contributing authors. The views and opinions expressed are those of the submitting authors and do not necessarily reflect those of The Journal of Integrative Medicine, The American Academy of Integrative Medicine, The American Academy of Preventive Medicine, any advertisers or staff members of The Journal of Integrative Medicine