The Journal of Integrative Medicine On-Line
The Institute of Preventive Medicine
The American Academy of Integrative Medicine
The American Academy of Preventive Medicine

A journal committed to the philosophy of medicine that requires physicians to offer their patients all that is safe and effective without any subservience to one or more schools of medical thought.

Next Scheduled Update May 24, 2006

Most Requested Articles
The Journal of Integrative Medicine Volume 1 Number 1

AA Oxidopathy

Improved Myocardial Perfusion

 Volume 2
Number 1
Oxidative Regression to Primordial Cellular Ecology (ORPEC)

 Volume 3 Number 1
Editorial: Under Darwin's Glow

Darwin, Fatigue, and Fibromyalgia

Darwin, Oxidosis, Dysoxygenosis, and Integration

Fibromyalgia: An Oxidative-Dysoxygenative Disorder (ODD)

ODD Trigger Points in Fibromyalgia: Pathogenesis, Diagnosis, and Resolution

 Volume 7 Number 1
The Oxidative-Dysoxygenative Model of Aging.

The Cause of Fibromyalgia:
the respiratory -to-fermentative shift
(the DysOx State)
in ATP production.

This site is still under construction
Next update
May 25, 2005

 

J Integrative Medicine 1998;2:4-55
Oxidative Regression to Primordial Cellular Ecology (ORPEC)

OXIDATIVE REGRESSION TO PRIMORDIAL CELLULAR ECOLOGY (ORPEC):
Evidence for the Hypothesis
and Its Clinical Significance
Majid Ali, M.D.

OUTLINE
I. Abstract

II. Introduction

III.  The ORPEC Hypothesis

IV. Morphology of Primordial Life Forms (PLFs)

V. The Effects of Hydrogen Peroxide and Ozone on Erythrocyte Morphology

VI. Oxygen Order of Human Biology

VII. History of Oxygen During the Primordial Era

VIII. Primordial Cellular Ecology

IX. High Level of Homology Between Yeast and Mammalian DNA Sequences

X. Gene Swapping In Nature

XI. Oxidative Injury to 3M Ecologies

XII. Oxidative Injury to 3C Cascades

XIII. Oxidative Oxygenative Dysfunctions

XIV. Phytooxidants, Phytoantioxidants and the ORPEC State

XV. Evolving Concepts of Mycosis and PLFs

XVI. Clinical Syndromes of Accelerated Oxidative Molecular Injury to Human Ecosystems

XVII. Paradox of In Vitro Oxidants Serving As In Vivo Antioxidant Therapies

XVIII. The Pyramid of Trios of the Body Ecosystems

XIX. Microecologic (cellular) and macroecologic (tissue-organ) Ecosystems

XX. Clinical Significance of the ORPEC State:

XXI. Conclusions

I. ABSTRACT

In clinical states characterized by chronically accelerated oxidative stress, enzyme systems involved in oxygen transport and utilization, redox regulation, and acid-base equilibrium are severely impaired. Such oxidative states include fibromyalgia, chronic fatigue syndrome (CFS), Gulf War syndrome, severe immune disorders, and malignant neoplasms. It is proposed that normal "oxygenative" cellular ecology in such states undergoes an "oxidative regression to primordial cellular ecology" (ORPEC) in which state progressive anoxia, acidosis, excess reactive oxidative species, and accumulation of certain organic acids create cellular ecologic conditions that closely simulate the primordial state. The ORPEC state results in rapid multiplication in blood and tissues of pleomorphic anaerobic organisms with yeast-like morphologic features, which are designated "primordial life forms" (PLFs) for lack of precise nucleotide sequence and taxonomic data. PLFs are readily observed with high-resolution phase-contrast and darkfield microscopy in freshly prepared and unstained smears of peripheral blood. Strong homology among yeast and mammalian DNA sequences indicates that the genetic codes for PLF growth may already exist in human cells and that organisms observed in this study may not indicate an infection from an outside source. Rather, the clinical syndromes associated with PLF proliferation may represent a novel "microecologic-genetic" model of illness. Organic acids and other toxins produced by the growing number of PLFs further feed the oxidative flames of the ORPEC state, thus generating oxidative cycles that feed upon each other and are damaging to antioxidant and oxygenative enzyme systems of the body.

The proposed ORPEC hypothesis draws its primary support from the microscopic findings presented in this paper when these are considered in light of the following: (1) the fundamental "oxygen order" of human biology; (2) the history of oxygen during the primordial era; (3) the primordial cellular ecology as reconstructed from the origin-of-life studies; (4) morphologic evidence of accelerated oxidative injury to all components of circulating blood (oxidative coagulopathy), and to cell membranes, intracellular matrix, and cell organelles such as mitochondria (AA oxidopathy); (5) oxidative oxygenative dysfunctions (pathologic states characterized by impaired cellular oxygenation and caused by oxidative injury); (6) a high level of homology among yeast and mammalian nucleotide sequences (reflecting conserved primordial nucleotide sequences) that may lead to de novo growth of PLFs under primordial conditions; (7) phenomenon of gene swapping in nature that may enlarge the cellular genetic pool ; (8) oxidative 3 C cascades that contribute to and perpetuate primordial conditions; (9) evolving concepts of mycosis and PLFs; (10) increased urinary excretion of certain organic acids that provide biochemical evidence of overgrowth of yeast and PLFs in patients in the ORPEC state; and (11) clinical syndromes of accelerated oxidative molecular injury.

Orpec 1 | 2 | 3  | 4  | 5  | 6  | 7  | 8  |  9  | 10  | 11  | 12  | 13  | 14  | 15  | 16  | 17  | 18  | 19  | 20  | 21 | 22  | 23  | 24 | 25  | 26  | 27  | 28  | 29  | 30
 

Index of Article Authors
Majid Ali, MD
Omar Ali, MD
Mary Ann Carroll, RN
Alfred Fayemi, MD
C.Grieder-Brandenburger, RN
Judy Juco, MD
Tsuneo Kobayashi MD
Jean A. Monro, MB, BS
(This index is incomplete and will be completed shortly)

Past and
Current Editors
Omar Ali, M.D.
Robert Atkins, M.D.
Robert Bradford, D.Sc
Paul Cheney, M.D., Ph.D.
Steven Davies, M.D.
Alfred O. Fayemi, M.D.
Claus Hanke, M.D.
Doug Hutto, N.D.
Judy Juco, M.D.
Paris Kidd, Ph.D.
Oscar Kruesi, M.D.
Derrick Lonsdale, M.D.
D. Vijen Poleszynski, B.S.
Christine Radulescu, Ph.D.
Ray Russamono, M.D.
Susan Test, Ph.D.
Lowell Weiner, D.D.S.
John C. Williams, M.D.

The Journal of Integrative Medicine shall not be held responsible for statements of the contributing authors. The views and opinions expressed are those of the submitting authors and do not necessarily reflect those of The Journal of Integrative Medicine, The American Academy of Integrative Medicine,
The American Academy of Preventive Medicine, any advertisers or staff members of The Journal of Integrative Medicine
 

Contacting our offices

The Journal of Integrative Medicine shall not be held responsible for statements of the contributing authors. The views and opinions expressed are those of the submitting authors and do not necessarily reflect those of The Journal of Integrative Medicine, The American Academy of Integrative Medicine, The American Academy of Preventive Medicine, any advertisers or staff members of The Journal of Integrative Medicine